From the dissection of T, B and NK cell signaling pathways to the 3D structure of a T cell receptor-antigenic peptide-MHC complex through the composition of the death signal delivered by T cytolytic lymphocytes and the analysis of the myeloid lineage, the research led by the CIML scientists has contributed to establish the major organization principles governing the immune system, and opened the way to new diagnostic and therapeutic solutions.

In contact with other sciences, at the interface between physiology and pathology, CIML scientists are now attempting to predict and manipulate the immune system by combining, at the era of functional genomics and systems biology, in vivo analysis and the study of patients.

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Research teams:

Immunobiology of stromal cell
Marc Bajénoff

Innate immunity at mucosal sites
Achille Broggi

Dendritic cells and antiviral defence
Marc Dalod

B cell Immunity to Infection
Mauro Gaya

Membrane dynamics and T lymphocyte signaling
Hai-Tao He & Didier Marguet

Immune tolerance and T cell differentiation
Magali Irla

Inflammation biology group
Toby Lawrence

Integrative B cell immunology
Pierre Milpied

Genomic instability and human hemopathies
Bertrand Nadel and Sandrine Roulland

Dendritic cell biology
Philippe Pierre

Integrative biology of T cells
Romain Roncagalli

Immunosurveillance of the central nervous system
Rejane Rua

Innate lymphoid cells and Neural Regulation of Immunity
Sophie Ugolini

Development of the immune system
Serge Van De Pavert

Innate lymphoid cells
Eric Vivier


Associated Projects:


Alumni & emeritus:


Lena Alexopoulou

Giovanna Chimini

Jonathan Ewbank

Pierre Ferrier

Michel Fougereau

Pierre Golstein

Jean Pierre Gorvel

Marie and Bernard Malissen

Philippe Naquet

Claudine Schiff

Anne Marie Schmitt-Verhulst

Michael Sieweke


CIML Publications