From the dissection of T, B and NK cell signaling pathways to the 3D structure of a T cell receptor-antigenic peptide-MHC complex through the composition of the death signal delivered by T cytolytic lymphocytes and the analysis of the myeloid lineage, the research led by the CIML scientists has contributed to establish the major organization principles governing the immune system, and opened the way to new diagnostic and therapeutic solutions.

In contact with other sciences, at the interface between physiology and pathology, CIML scientists are now attempting to predict and manipulate the immune system by combining, at the era of functional genomics and systems biology, in vivo analysis and the study of patients.

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Research teams:

Stromal cell Immunobiology
Marc Bajénoff

Dendritic cells and antiviral defence
Marc Dalod

Innate immunity in C. elegans
Jonathan Ewbank

B cell Immunity to Infection
Mauro Gaya

Immunology and cell biology of pathogen/host cell interactions
Jean Pierre Gorvel

Membrane dynamics and T lymphocyte signaling
Hai-Tao He & Didier Marguet

Genetic dissection of the function of T cells and dendritic cells
Marie and Bernard Malissen

Integrative B cell immunology
Pierre Milpied

Genomic instability and human hemopathies
Bertrand Nadel

Tissue inflammation and immunity
Philippe Naquet

Dendritic cell biology
Philippe Pierre

Immunosurveillance of the central nervous system
Rejane Rua

Innate lymphoid cells and Neural Regulation of Immunity
Sophie Ugolini

Development of the immune system
Serge Van De Pavert

Associated teams:

Inflammation biology group
Toby Lawrence

Stem cell and macrophage biology
Michael Sieweke

Innate lymphoid cells
Eric Vivier

Alumni & emeritus:

Lena Alexopoulou

Giovanna Chimini

Pierre Ferrier

Michel Fougereau

Pierre Golstein

Claudine Schiff

Anne Marie Schmitt-Verhulst

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