From the dissection of T, B and NK cell signaling pathways to the 3D structure of a T cell receptor-antigenic peptide-MHC complex through the composition of the death signal delivered by T cytolytic lymphocytes and the analysis of the myeloid lineage, the research led by the CIML scientists has contributed to establish the major organization principles governing the immune system, and opened the way to new diagnostic and therapeutic solutions.
In contact with other sciences, at the interface between physiology and pathology, CIML scientists are now attempting to predict and manipulate the immune system by combining, at the era of functional genomics and systems biology, in vivo analysis and the study of patients.
Research teams:
Immunobiology of stromal cell
Marc Bajénoff
Innate immunity at mucosal sites
Achille Broggi
Dendritic cells and antiviral defence
Marc Dalod
B cell Immunity to Infection
Mauro Gaya
Membrane dynamics and T lymphocyte signaling
Hai-Tao He & Didier Marguet
Immune tolerance and T cell differentiation
Magali Irla
Inflammation biology group
Toby Lawrence
Integrative B cell immunology
Pierre Milpied
Genomic instability and human hemopathies
Bertrand Nadel and Sandrine Roulland
Dendritic cell biology
Philippe Pierre
Integrative biology of T cells
Romain Roncagalli
Immunosurveillance of the central nervous system
Rejane Rua
Innate lymphoid cells and Neural Regulation of Immunity
Sophie Ugolini
Development of the immune system
Serge Van De Pavert
Innate lymphoid cells
Eric Vivier
Associated Projects:
PROJECT. MECHANOBIOLOGY & INNATE IMMUNITY IN C. ELEGANS
Alumni & emeritus:
Ressources
