Events

Sylvia CREMER, Institute of Science and Technology, Klosterneuburg, AT
Host: Jonathan EWBANK

Sophie ACTON, Laboratory for Molecular Cell Biology, UCL, London, UK
Host: Marc BAJENOFF

Kiavash MOVAHEDI, Vlaams Institut voor Biotechnologie, Gent, BE
Host: Rejane RUA

News

Covid-19, the CIML is mobilising for the AP-HM
Research institutes of the CNRS, Inserm and AMU, on the Luminy campus, including the CIML,…

Cellule de veille "Epidémie Covid-19" de l'Académie Nationale de Médecine
Composition et missions de la cellule de veille « Épidémie Covid-19 »
Dans le cadre de la…

CENTURI International PhD call, 18 Open positions starting in October 2020
The Turing Centre for Living Systems (CENTURI) wishes to attract talented PhD students to the…

HEADLINE

A newly discovered memory in our bones: blood stem cells boost immunity by keeping a record of previous infections

CSC-MS

A Franco-German research team led by Prof. Michael Sieweke, from the Center for Regenerative Therapies TU Dresden (CRTD) and the Center of  Immunology of Marseille Luminy (CNRS, INSERM, Aix-Marseille University), today uncovered a surprising property of blood stem cells: not only do they ensure the continuous renewal of blood cells and contribute to the immune response triggered by an infection, but they can also remember previous infectious encounters to drive a more rapid and more efficient immune response in the future. These findings should have a significant impact on future vaccination strategies and pave the way for new treatments of an underperforming or over-reacting immune system. The results of this research are published in Cell Stem Cell on March 12, 2020. More information

C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells
de Laval B., Maurizio J., Kandalla P K., Brisou G., Simonnet L., Huber C., Gimenez G., Matcovitch-Natan O., Reinhardt S., David E., Mildner A., Leutz A., Nadel B., Bordi C., Amit I., Sarrazin S.*,†., Sieweke M H.*,†. Cell Stem Cell, 2020 , pii: S1934-5909(20)30017-5, PMID: 32169166

When Stress Weakens the Immune Defenses

SU-JEM

In previous years, various studies have established a link between psychological stress and reduced immune defenses, but the mechanisms involved remained poorly elucidated. Sophie Ugolini, Inserm Research Director at the Center of Immunology Marseille-Luminy, and her colleagues at CNRS and Aix-Marseille Université have recently shown that such a link is to a large extent mediated by a type of receptor that binds to stress hormones: the β2-adrenergic receptor. Their findings have been published in Journal of Experimental Medicine. More information

β2-adrenergic signals downregulate the innate immune response and reduce host resistance to viral infection Wieduwild E, Girard-Madoux MJ, Quatrini L, Laprie C, Chasson L, Rossignol R, Bernat C, Guia S, Ugolini S. J Exp Med., 2020 , 217(4), PMID: 32045472

What is Immunology

At the crossroads of biology and medicine, immunology is a scientific discipline that focuses on the operating mechanisms of the immune system. Appeared early in the evolution, this system enables living organisms to defend themselves against pathogens or their own components when they are altered. It involves a large number of cells whose capacity for cooperation, recognition and memory are far from having revealed all their secrets.

Publications

Crinier A. et al., Cell, , 180: 6, P1280-1280.e1
Guilliams M. et al., Immunity, , 52(3):434-451, PMID: 32187515
Wohn C. et al., Sci Immunol. , , 5(45). pii: eaba1896, PMID: 32169954
de Laval B. et al., Cell Stem Cell, , pii: S1934-5909(20)30017-5, PMID: 32169166
Gauthier L. et al., Cell, , 180(5):822-824, PMID: 32142673
Etzerodt A. et al., J Exp Med, , 217 (4): e20191869
McCarron MJ, Irla M. et al., Nat Commun., , 10(1):5690., PMID: 31857584
Valente M. et al., Proc Natl Acad Sci U S A., , pii: 201913491. doi: 10.1073/pnas.1913491116, PMID: 31796596

Enseignement

CIML ERC GRANTS

ERC "Advanced Grants"
Bernard Malissen – 2018 – Basilic Projet
Michael Sieweke – 2016 – Macrophage Aging and Rejuvenation
Eric Vivier – 2016 – Targeting  Innate Lymphoid Cells
Bernard Malissen – 2012 – Integrative biology of T cells and dendritic cells in vivo
Eric Vivier – 2010 – The Immune Function of Natural Killer
ERC "Consolidator Grants"
Sophie Ugolini – 2014 – Neural regulation of immunity
Marc Bajénoff – 2014 – Immunobiology of lymphoid stromal cells
ERC "Starting Grants"
Marc Dalod – 2011 – Harnessing systems immunology to unravel dendritic cell subset biology
Toby Lawrence - 2010 – Targeting tumor associated macrophages in Cancer
ERC "Proof of Concept (PoC) Grant"
Eric Vivier - 2019 - MInfla-Tilc

Vidéos

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Marseille Immunopole

The french immunology cluster.