Pedro ROMERO, UNIL, Ludwig Cancer Research Center, Lausanne, CH
Host: Bernard MALISSEN

Maria TSOUMAKIDOU, MD PhD, Institute of Bioinnovation, BSRC Alexander Fleming, Athens, Greece
"Tumor Immune Tolerance Mediated by Dendritic Cells: Opportunities for…

EMDS 2019 «33rd Annual Conference : European Macrophage and Dendritic cell Society », Septembre 12,13 eand14 at the World Trade Center in Marseille. The mononuclear phagocyte…


Michel PIERRES, a world-renowned physician and immunologist, died on June 14, 2019
One of the first team leaders of the CIML, Michel Pierres was director of the centre from…

Le rapport d'activité Inserm 2018 vient de paraitre
Parmi les avancées scientifiques de l'année 2018, en page 9, un article sur les travaux de l'équipe d'Eric VIVIER…

A study by the Bernard Malissen (CIML CNRS, Inserm, AMU Marseille), M. Gstaiger (IMSB) and R. Aebersold (IMSB) groups  which appeared in Cell Reports, identifies using proteomics…

Michel Pierres

Michel PIERRES, a world-renowned physician and immunologist, died on June 14, 2019

One of the first team leaders of the CIML, Michel Pierres was director of the centre from 1991 to 1995. His work on the characterization of molecules associated with T lymphocyte activation using monoclonal antibodies helped to position the Centre d’Immunologie de Marseille-Luminy (CIML) on the map of global immunology during the 1980s to 2000s..

Michel Pierres will be remembered for his sense of ethics, methodological rigor, incomparable energy, generosity towards fellow researchers around the world and his profound scientific and general culture (literary and musical in particular). He was a colleague and friend highly esteemed by his peers.

More information



cellreportsBMMImmunotherapy shows spectacular success in treating cancers, but unfortunately only in a minority of patients. A study by the Gstaiger (IMSB), Aebersold (IMSB), and Bernard Malissen group (Centre d'Immunologie de Marseille-Luminy - CIML CNRS, Inserm, AMU Marseille), which appeared in Cell Reports, identifies using proteomics and mouse models molecular mechanisms that might account for some of the failures observed during immunotherapy.

Quantitative Interactomics in Primary T Cells Provides a Rationale for Concomitant PD-1 and BTLA Coinhibitor Blockade in Cancer Immunotherapy
Celis-Gutierrez J, Blattmann P, Zhai Y, Jarmuzynski N, Ruminski K, Grégoire C, Ounoughene Y, Fiore F, Aebersold R, Roncagalli R, Gstaiger M, Malissen B. Cell Rep., 2019

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2019 PhD Calls

1- Alexopoulou Lena "TLR7 at the interface of obesity and metabolic syndrome"
2- Arguello Rafael & Ewbank Jonathan "Translation regulation during infection and stress"
3- Auphan-Anezin Nathalie "Role of IKKb/NF-kB signaling in the immune surveillance of melanomas"
4- Bajénoff Marc "Macrophage-Stroma crosstalk in lymphoid organs"
5- Gaya Mauro "Deciphering the early events of B cell immunity in the lung mucosa"
6- Hamon Yannick & He Hai-Tao "Unravel the link between TCR, IFN-γR and cholesterol/ABCs pathways in CD4 T cell"
7- Henri Sandrine "Deciphering the Tumor-associated Myeloid Cell Heterogeneity: Toward a Better understanding and better manipulation of XCR1+ cDC1 and tumor-associated macrophages in vivo to improve cancer-immunotherapy and avoid auto-immunity"
8- Irla Magali "Characterizing a novel immune checkpoint controlling the suppressive activity of regulatory T cells"
9- Lelouard Hugues "Rôle du système phagocytaire des plaques de Peyer dans l’initiation de la réponse immunitaire intestinale"
10- Memet Sylvie "Analysis of the signalling induced by Brucella oligosaccharides in the inflammatory response"
11- Payet Dominique "Role of PTEN in thymopoiesis and leukemogenesis"
12- Pujol Nathalie "How are damage responses triggered in the skin?"
13- Roulland Sandrine "Integrative study of B Cell Receptor signaling pathway in B cell lymphoma and therapeutic targeting"
14- Sieweke Michael "De la cellule souche au macrophage : transmission d’une mémoire épigénétique ?"
15- Tomasello Elena "Etude des fonctions physiologiques des cellules dendritiques plasmacytoïdes"
16- Ugolini Sophie "Regulation of the skin immune response by the sensory nervous system"
17- Van de Pavert "Ontogeny of Innate Lymphoid Cells"

See the projects

What is Immunology

At the crossroads of biology and medicine, immunology is a scientific discipline that focuses on the operating mechanisms of the immune system. Appeared early in the evolution, this system enables living organisms to defend themselves against pathogens or their own components when they are altered. It involves a large number of cells whose capacity for cooperation, recognition and memory are far from having revealed all their secrets.


Celis-Gutierrez J. et al., Cell Rep., , 27(11):3315-3330.e7. doi: 10.1016/j.celrep.2019.05.041, PMID: 31189114
Gauthier L. et al., Cell, , pii: S0092-8674(19)30460-X. doi: 10.1016/j.cell.2019.04.041, PMID: 31155232
Mondor I. et al., Immunity, , pii: S1074-7613(19)30182-7., PMID: 31053503
Goossens P. et al., Cell Metab., , pii: S1550-4131(19)30128-7, PMID: 30930171
Thierry GR. et al., J Exp Med., , 215, 12, PMID: 30429248
Gentek R. et al., J Exp Med., , pii: jem.20181206, PMID: 30409784
Chiossone L. et al., Nature Reviews Immunology, , 18:671-688



ERC "Advanced Grants"
Bernard Malissen – 2018 – Basilic Projet
Michael Sieweke – 2016 – Macrophage Aging and Rejuvenation
Eric Vivier – 2016 – Targeting  Innate Lymphoid Cells
Bernard Malissen – 2012 – Integrative biology of T cells and dendritic cells in vivo
Eric Vivier – 2010 – The Immune Function of Natural Killer
ERC "Consolidator Grants"
Sophie Ugolini – 2014 – Neural regulation of immunity
Marc Bajénoff – 2014 – Immunobiology of lymphoid stromal cells
ERC "Starting Grants"
Marc Dalod – 2011 – Harnessing systems immunology to unravel dendritic cell subset biology
Toby Lawrence - 2010 – Targeting tumor associated macrophages in Cancer


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Marseille Immunopole

The french immunology cluster.