A team of researchers from CNRS, Inserm and Aix-Marseille University (AMU) at the Centre d’Immunologie de Marseille-Luminy, in collaboration with the Singapore Immunology Network, has demonstrated that mast cells, key cells of the immune system, are not all generated in the bone marrow contrary to what has been established so far. Scientists have identified mast cells of embryonic origin in mice that probably have different functions than mast cells in adults. This study is published in Immunity this June 2018.
Gentek R. et al., Immunity, 2018
© Rebecca Gentek/CIML – Imagerie confocale de la peau d’un souriceau nouveau-né. Les mastocytes apparaissent en vert, les vaisseaux sanguins en gris et l’épiderme en rouge.
At the crossroads of biology and medicine, immunology is a scientific discipline that focuses on the operating mechanisms of the immune system. Appeared early in the evolution, this system enables living organisms to defend themselves against pathogens or their own components when they are altered. It involves a large number of cells whose capacity for cooperation, recognition and memory are far from having revealed all their secrets.
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Pr Eric VIVIER and Dr Bernard MALISSEN have been selected for the Thomson Reuters 2016 and 2017 lists of Highly Cited Researchers