Events

Jean ROUDIER, UMR S 1097 GENES HLA-DR, Aix-Marseille Université, Marseille, FR
"Molecular basis for the association between HLA-DR and Rheumatoid arthritis- Towards a new…

Frédéric RIEUX-LAUCAT, Institut Imagine, Hôpital Necker, Paris
"The genetic landscape of pediatric lupus and autoimmune syndrome"
host: Philippe PIERRE…

Wonhwa CHO, University of Illinois, Chicago, USA
Host: Yannick HAMON

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News

L'ouvrage : La nouvelle immunothérapie des cancers vient de paraitre aux éditions John Libbey. Ouvrage collectif coordonné par François Ghiringhelli et Eric Vivier, Professeur au…

The team of Dr Marc BAJENOFF, CNRS researcher at the Centre d’Immunologie de Marseille-Luminy, CNRS, Inserm and Aix-Marseille University (AMU), in collaboration with the Singapore…

The CIML participated to the first Inserm festival with the participation of Sandrine SARRAZIN, Rafael ARGUELLO and Yannick HAMON, researchers at the Centre d'…

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In search of the origins of mast cells

Immunity-2018-MB

A team of researchers from CNRS, Inserm and Aix-Marseille University (AMU) at the Centre d’Immunologie de Marseille-Luminy, in collaboration with the Singapore Immunology Network, has demonstrated that mast cells, key cells of the immune system, are not all generated in the bone marrow contrary to what has been established so far. Scientists have identified mast cells of embryonic origin in mice that probably have different functions than mast cells in adults. This study is published in Immunity this June 2018.
Gentek R. et al., Immunity, 2018

© Rebecca Gentek/CIML – Imagerie confocale de la peau d’un souriceau nouveau-né. Les mastocytes apparaissent en vert, les vaisseaux sanguins en gris et l’épiderme en rouge.

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What is Immunology

At the crossroads of biology and medicine, immunology is a scientific discipline that focuses on the operating mechanisms of the immune system. Appeared early in the evolution, this system enables living organisms to defend themselves against pathogens or their own components when they are altered. It involves a large number of cells whose capacity for cooperation, recognition and memory are far from having revealed all their secrets.

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Publications

Hemogenic endothelial fate mapping reveals dual developmental origin of mast cells
Rebecca Gentek. et al., Immunity,
An early history of T cell-mediated cytotoxicity
Golstein P. et al., Nat Rev Immunol., , PMID: 29662120
Lymphotoxin α fine-tunes T cell clonal deletion by regulating thymic entry of antigen-presenting cells
Lopes N. et al., Nat Commun., , 9(1):1262, PMID: 29593265
Unveiling skin macrophage dynamics explains both tattoo persistence and strenuous removal
Baranska A. et al., J Exp Med., , PMID: 29511065
The immunological functions of the Appendix: An example of redundancy?
Girard-Madoux MJH. et al., Semin Immunol. , , PMID: 29503124
Guanabenz inhibits TLR9 signaling through a pathway that is independent of eIF2α dephosphorylation by the GADD34/PP1c complex
Perego J. et al., Sci Signal. , , 11(514), PMID: 29363586
Receptor Activator of NF-κB Orchestrates Activation of Antiviral Memory CD8 T Cells in the Spleen Marginal Zone
Habbeddine M. et al., Cell Rep., , 21(9):2515-2527, PMID: 29186688
Trained macrophages support hygiene hypothesis
de Laval B. et al., Nat Immunol., , 18(12):1279-1280, PMID: 29144502
Host resistance to endotoxic shock requires the neuroendocrine regulation of group 1 innate lymphoid cells
Quatrini L. et al., J Exp Med.,
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Enseignement

Thomson Reuters list of highly cited researchers

Pr Eric VIVIER and Dr Bernard MALISSEN have been selected for the Thomson Reuters 2016 and 2017 lists of Highly Cited Researchers

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Marseille Immunopole

The french immunology cluster.

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