The Center for Immunologie of Marseille-Luminy (CIML) announces the publication of a major scientific review in the prestigious journal Immunity, entitled "Role of specialized sensory neuron subtypes in modulating peripheral immune responses."
This review, led by Dr. Sophie Ugolini, Inserm Research Director and team leader at CIML, in collaboration with Théo Crosson and Ninon Bretaud, examines recent advances regarding the complex interactions between the sensory nervous system and the immune system.
This review highlights how different populations of sensory neurons specifically regulate various immune responses. Sensory neurons, whose peripheral nerve endings reside in tissues throughout the body, display remarkable heterogeneity. The authors detail how these neurons, beyond their role in transmitting pain, itch, or other sensations, actively modulate immune functions through the release of neuropeptides, neurokines, or glutamate.
This functional specialization enables precise immunomodulation adapted to the kinetics and nature of immune responses, positioning sensory neurons as key regulators of host defense and tissue homeostasis.
The publication of this review constitutes a significant advancement for the scientific community, offering an integrated view of neuro-immune mechanisms that could open new therapeutic perspectives in the treatment of inflammatory and infectious diseases.
https://authors.elsevier.com/a/1l1-f3qNrU-hlm
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