Redundant processes in Immunotherapy signaling processes revealed

L'immunothérapie montre un succès spectaculaire dans le traitement de certains cancers, mais malheureusement seule une minorité de patients en bénéficie. Une étude du groupe de M. Gstaiger (IMSB), R. Aebersold (IMSB) et Bernard Malissen (Centre d'Immunologie de Marseille-Luminy - CIML, CNRS, Inserm, AMU Marseille), publiée dans Cell Reports, identifie les mécanismes moléculaires pouvant expliquer certains des échecs observés pendant l'immunothérapie.

Quantitative Interactomics in Primary T Cells Provides a Rationale for Concomitant PD-1 and BTLA Coinhibitor Blockade in Cancer Immunotherapy
Celis-Gutierrez J, Blattmann P, Zhai Y, Jarmuzynski N, Ruminski K, Grégoire C, Ounoughene Y, Fiore F, Aebersold R, Roncagalli R, Gstaiger M, Malissen B. Cell Rep., 2019

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2019 PhD Calls

1- Alexopoulou Lena "TLR7 at the interface of obesity and metabolic syndrome"
2- Arguello Rafael & Ewbank Jonathan "Translation regulation during infection and stress"
3- Auphan-Anezin Nathalie "Role of IKKb/NF-kB signaling in the immune surveillance of melanomas"
4- Bajénoff Marc "Macrophage-Stroma crosstalk in lymphoid organs"
5- Gaya Mauro "Deciphering the early events of B cell immunity in the lung mucosa"
6- Hamon Yannick & He Hai-Tao "Unravel the link between TCR, IFN-γR and cholesterol/ABCs pathways in CD4 T cell"
7- Henri Sandrine "Deciphering the Tumor-associated Myeloid Cell Heterogeneity: Toward a Better understanding and better manipulation of XCR1+ cDC1 and tumor-associated macrophages in vivo to improve cancer-immunotherapy and avoid auto-immunity"
8- Irla Magali "Characterizing a novel immune checkpoint controlling the suppressive activity of regulatory T cells"
9- Lelouard Hugues "Rôle du système phagocytaire des plaques de Peyer dans l’initiation de la réponse immunitaire intestinale"
10- Memet Sylvie "Analysis of the signalling induced by Brucella oligosaccharides in the inflammatory response"
11- Payet Dominique "Role of PTEN in thymopoiesis and leukemogenesis"
12- Pujol Nathalie "How are damage responses triggered in the skin?"
13- Roulland Sandrine "Integrative study of B Cell Receptor signaling pathway in B cell lymphoma and therapeutic targeting"
14- Sieweke Michael "De la cellule souche au macrophage : transmission d’une mémoire épigénétique ?"
15- Tomasello Elena "Etude des fonctions physiologiques des cellules dendritiques plasmacytoïdes"
16- Ugolini Sophie "Regulation of the skin immune response by the sensory nervous system"
17- Van de Pavert "Ontogeny of Innate Lymphoid Cells"

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