News | CIML

Thu, 09/13/2018 - 12:00

How to produce in the laboratory the most effective dendritic cells against cancer?

Dendritic cells, leaders of immunity orchestras, are promising targets for vaccination or immunotherapy.…

Wed, 08/15/2018 - 12:00
ResearchGate
Immune cell type best suited for cancer vaccines can now be grown in the lab
New approach paves the way to making dendritic…

Tue, 08/14/2018 - 12:00
Balan S. et al., Cell Reports, 2018
The team of Marc DALOD, CNRS Team Leader at the Centre d'Immunologie de Marseille-Luminy, CNRS, Inserm and Aix-Marseille…

Tue, 08/14/2018 - 12:00
Mount Sinai
Researchers Artificially Generate Immune Cells Integral To Creating Cancer Vaccines
…

Wed, 03/09/2016 - 12:00
Dendritic cells XCR1 – the memory lymphocyte whisperers
As part of Marc Dalod’s team, Karine Crozat, Yannick Alexandre and their coworkers have shed new light on the role…

Team leader

Marc DALOD, DR2, PhD

See biography...

The team

Abdenour
ABBAS

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ABBAS Abdenour

Doctorant, Université

Marc
AMBROSINI

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AMBROSINI Marc

IE2, INSERM

Gilles
BESSOU

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BESSOU Gilles

IE1, INSERM

Gilles Bessou joined the team at its vey beginning in 2004 as a tenure engineer from Inserm. He is managing the laboratory and many of the mouse colonies used by the team. He contributes to transferring or developing novel experimental protocols in the team. He also is the Hygiene and Security officer for the CIML Institute with regards to biohazard, especially for everything linked to the operating of level 2 or 3 laboratories.

Jean charles
CANCEL

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CANCEL Jean charles

Autre stage, INSERM

Jean-Charles Cancel joined the team in 2016 as a PhD student supported by the « Ligue Nationale contre le Cancer ». His work is focused on the study of the role of XCR1+ dendritic cells in tumor immunosurveillance and during immunotherapies against cancer.

Karine
CROZAT

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CROZAT Karine

CR1, CNRS

Karine Crozat joined CIML in 2008 as a post doctoral fellow after completing her PhD work at The Scripps Research Institute in La Jolla, USA. Dr Crozat’s research focuses on dissecting the functions of CD8α+ dendritic cells in innate and adaptive immune responses to viruses, bacteria and tumors in mice. Profil Linkedin: http://fr.linkedin.com/pub/karine-crozat/3/6b4/428

Raphael
MATTIUZ

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MATTIUZ Raphael

Doctorant, Université

Karima
NACIRI

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NACIRI Karima

IE2, Université

Elena
TOMASELLO

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TOMASELLO Elena

CR1, CNRS

Elena Tomasello, PhD, CR1 CNRS, Italian Senior Researcher, joined the team in 2012.
Her main research interest is the dissection of the molecular mechanisms regulating the functional heterogeneity of mouse and human plasmacytoid dendritic cells.

Thien phong
VU MANH

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VU MANH Thien phong

CR1, CNRS

After a 2-year postdoctoral experience at the Centre for Genomic Regulation (CRG, Barcelona, Spain), Thien-Phong joined the CIML in 2010 as a post-doc fellow. He is now a CNRS researcher and is interested in deciphering, using bulk and single cell genomics approaches, the cell-intrinsic and -extrinsic regulation that occurs in dendritic cells and more generally mononuclear phagocytes, how this instructs cell differentiation/activation, and how the interplay between different types and activation states of mononuclear phagocytes manages and fine tunes the immune response.

Selected publications

Broad and Largely Concordant Molecular Changes Characterize Tolerogenic and Immunogenic Dendritic Cell Maturation in Thymus and Periphery
Ardouin L., Immunity, 2016 , PMID: 27533013

XCR1+ dendritic cells promote memory CD8+ T cell recall upon secondary infections with Listeria monocytogenes or certain viruses
Alexandre YO., J Exp Med., 2016 , PMID: 26694969

Natural Killer Cell Sensing of Infected Cells Compensates for MyD88 Deficiency but Not IFN-I Activity in Resistance to Mouse Cytomegalovirus
Cocita C., PLoS Pathog., 2015 , PMID: 25954804

Human XCR1+ dendritic cells derived in vitro from CD34+ progenitors closely resemble blood dendritic cells, including their adjuvant responsiveness, contrary to monocyte-derived dendritic cells
Balan S., J Immunol., 2014 , 1622-35, PMID: 25009205

Differential responses of immune cells to type I interferon contribute to host resistance to viral infection
Baranek T., Cell Host Microbe, 2012 , 571-584, PMID: 23084923

Cutting Edge: Expression of XCR1 Defines Mouse Lymphoid-Tissue Resident and Migratory Dendritic Cells of the CD8{alpha}+ Type
Crozat K., J Immunol, 2011 , PMID: 21948982

The XC chemokine receptor 1 is a conserved selective marker of mammalian cells homologous to mouse CD8alpha+ dendritic cells
Crozat, K., J Exp Med, 2010 , 1283-92, PMID: 20479118

Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling
Robbins, S. H., Genome Biol, 2008 , R17, PMID: 18218067

Contact

Marc DALOD

Tel: +33 (0)4 91 26 94 51

Liens

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