A team of researchers from CNRS, Inserm and Aix-Marseille University (AMU) at the Centre d’Immunologie de Marseille-Luminy, in collaboration with the Singapore Immunology Network, has demonstrated that mast cells, key cells of the immune system, are not all generated in the bone marrow contrary to what has been established so far. Scientists have identified mast cells of embryonic origin in mice that probably have different functions than mast cells in adults. This study is published in Immunity this June 2018.
© Rebecca Gentek/CIML – Imagerie confocale de la peau d’un souriceau nouveau-né. Les mastocytes apparaissent en vert, les vaisseaux sanguins en gris et l’épiderme en rouge.
References
Hemogenic endothelial fate mapping reveals dual developmental origin of mast cells, Rebecca Gentek, Clément Ghigo, Guillaume Hoeffel, Maxime Jacques Bulle, Rasha Msallam, Gregory Gautier, Pierre Launay, Jinmiao Chen, Florent Ginhoux et Marc Bajénoff. Immunity, 2018.
Contacts
Chercheur CNRS l Marc Bajénoff l T +33(0)4 91 26 91 50 l bajenoff@ciml.univ-mrs.fr
Presse CNRS l Juliette Dunglas l T 01 44 96 46 34 l juliette.dunglas@cnrs.fr
1Singapore immunology network (SIgN) est rattaché à l’Agency for science, technology and research de Singapore (A*STAR)
