What if, in the face of infections, our immune system is not the only one to fight? What if his major ally actually turns out to be the brain?
Researchers from Inserm, CNRS and Aix-Marseille University (AMU) describe new mechanisms of cooperation between the nervous system and the immune system in the response to pathogenic infections. This work, published in the journal Nature Immunology, highlights the brain's involvement in regulating the inflammatory response induced by the immune system in response to infection. It also reveals the protective effect of these neuroimmune interactions against the damaging effects of inflammation.
References
Endogenous glucocorticoids control host resistance to viral infection through the tissue-specific regulation of PD-1 expression on NK cells
Linda Quatrini1, Elisabeth Wieduwild1, Bertrand Escaliere1, Jessica Filtjens1, Lionel Chasson1, Caroline Laprie1, Eric Vivier1,2,3 and Sophie Ugolini1
Nature Immunology, 2018
1 Aix Marseille University, CNRS, INSERM, Centre d’Immunologie de Marseille-Luminy, Marseille, France.
2 Innate Pharma Research Laboratories, Innate Pharma, Marseille, France.
3 Service d’Immunologie, Marseille Immunopole, Hôpital de la Timone, Assistance Publique des Hôpitaux de Marseille, Marseille, France.
Contact
Sophie UGOLINI
Directrice de recherche Inserm
Unité 1104 - Centre d’immunologie de Marseille – Luminy (CIML)
Directrice de l’équipe ERC : Neural regulation of immunity
Et membre de l’équipe Cellules innées lymphoïdes
+33 (0)4 91 26 94 44
e-mail
