The team of Marc BAJENOFF, from the Centre d’Immunologie de Marseille-Luminy (CNRS/Inserm/Aix-Marseille University), in collaboration with a team of the San Raffaele Institute led by Matteo Iannacone, has discovered that the microarchitecture of lymph nodes allows the release of antibodies to the bloodstream, a mandatory step to their delivery to the infected site. These antibodies are transported via collagen micro-conduits within the lymph node, in the manner of a tunnel or a water pipe. The results were published on November 14, 2018 in the Journal of Experimental Medicine.
Team
