Quatrini et al., Nature Immunol., 2018
The team of Sophie UGOLINI, Research Director at Inserm and team leader at the Centre d'Immunologie de Marseille-Luminy, Inserm, CNRS and Aix-Marseille University describes new mechanisms of cooperation between the nervous system and the immune system in the response to pathogenic infections. This work, published in the journal Nature Immunology, highlights the brain's involvement in regulating the inflammatory response induced by the immune system in response to infection.
How to produce in the laboratory the most effective dendritic cells against cancer?
Dendritic cells, leaders of immunity orchestras, are promising targets for vaccination or immunotherapy. However, their medical use is limited by the inability to produce large quantities of the best dendritic cells in vitro to activate lymphocytes capable of killing tumor or infected cells. The study published in the journal Cell Reports now makes it possible to consider using this type of dendritic cells as a cancer vaccine, particularly to improve the effect of immune control point inhibitors.
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In the face of infections, the brain and immune system cooperate
What if, in the face of infections, our immune system is not the only one to fight? What if his major ally actually turns out to be the brain?
Lab. Giovanna CHIMINI
AN INTERNATIONAL INNOVATOR
From identifying the complexity of the mammalian lipid ABC transporters and their role in immunity to developing BIOTRAIL, the AMIDEX international interdisciplinary program in Life Sciences, the pioneer Giovanna Chimini has been a team leader at the CIML from 1992 to 2010 and is now Associate Dean in charge of Research and International Relations at the Faculty of Sciences, Aix-Marseille University.
Balan S. et al., Cell Reports, 2018
The team of Marc DALOD, CNRS Team Leader at the Centre d'Immunologie de Marseille-Luminy, CNRS, Inserm and Aix-Marseille University, in collaboration with a team from "The Tisch Cancer Institute", Icahn School of Medicine at Mount Sinai in New York, has found a way to artificially generate a type of immune cell that could help make dendritic cell vaccines, a promising type of immunotherapy, more effective. This study is published in Cell Reports on August 14, 2018.
