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<o:shapelayout v:ext="edit"> <o:idmap v:ext="edit" data="1"/> </o:shapelayout></xml><![endif]--></head><body style="" bgcolor="white" lang="EN-US" link="blue" vlink="blue"> <div class="WordSection1"> <p style="margin: 0.1pt 0cm;"><span style="font-size: 14pt; font-family: Arial;"><o:p>&nbsp;</o:p></span></p> <p style="margin: 0.1pt 0cm; text-align: center;" align="center"><span class="GramE"><b style=""><span style="font-size: 18pt; font-family: Arial;">June 2011: The CIML now has a new website. These pages are no longer actively maintained.</span></b></span></p> <p style="margin: 0.1pt 0cm; text-align: center;" align="center"><span class="GramE"><b style=""><span style="font-size: 18pt; font-family: Arial;">Please visit <a href="http://www.ciml.univ-mrs.fr/technology/c-elegans-functional-genomics">the new pages</a>.<br> <br> <br> </span></b></span></p> <p style="margin: 0.1pt 0cm; text-align: center;" align="center"><span class="GramE"><b style=""><span style="font-size: 18pt; font-family: Arial;"><br> </span></b></span></p> <p style="margin: 0.1pt 0cm; text-align: center;" align="center"><span class="GramE"><b style=""><span style="font-size: 18pt; font-family: Arial;">The <i style="">C.&nbsp;elegans</i> functional genomics platform.</span></b></span><b style=""><span style="font-size: 18pt; font-family: Arial;"><o:p></o:p></span></b></p> <p style="margin: 0.1pt 0cm;"><span style="font-size: 14pt; font-family: Arial;"><o:p>&nbsp;</o:p></span></p> <p style="margin: 0.1pt 0cm;"><span style="font-size: 14pt; font-family: Arial;">Through funding from the <a href="http://rng.cnrg.fr/">RNG</a>, <a href="http://www.cnrs.fr/">CNRS</a> and <a href="http://www.inserm.fr/">INSERM</a>, support from <a href="http://www.genopole.univ-mrs.fr/">Marseille-Nice <span class="SpellE">Génopole</span></a> and the <a href="http://www.ciml.univ-mrs.fr/">CIML</a>, acting as coordinating laboratory for the </span><span style="font-size: 14pt;"><a href="vermidi:labs.html"><span style="font-family: Arial;">French <i style="">C. elegans</i> community</span></a></span><span style="font-size: 14pt; font-family: Arial;">, we have established a national functional genomics platform.<o:p></o:p></span></p> <p style="margin: 0.1pt 0cm;"><span style="font-size: 14pt; font-family: Arial;">This platform was previously awarded RIO status (RIO plateau technique) a <a href="http://www.cnrs.fr/SDV/Dept/plateforme.html">national evaluation</a> of technology platforms.<o:p></o:p></span></p> <p style="margin: 0.1pt 0cm;"><span style="font-size: 14pt; font-family: Arial;">Resources include the <span class="SpellE">ORFeome</span> and <span class="SpellE">RNAi</span> libraries, and the COPAS Biosort <a href="http://www.ciml.univ-mrs.fr/EWBANK_jonathan/Genopole.html">automated worm sorter</a>. An example of how these resources can be used is given below.<o:p></o:p></span></p> <p style="margin: 0.1pt 0cm;"><span style="font-size: 14pt; font-family: Arial;"><o:p>&nbsp;</o:p></span></p> <div style="border: 1pt solid windowtext; padding: 0cm 4pt 1pt;"> <div style="border: 1pt solid windowtext; padding: 0cm 4pt 1pt;"> <p style="border: medium none ; margin: 0.1pt 0cm; padding: 0cm; text-align: center;" align="center"><span style="font-size: 14pt; font-family: Arial;"><!--[if gte vml 1]><v:shapetype id="_x0000_t75" coordsize="21600,21600" o:spt="75" o:preferrelative="t" path="m@4@5l@4@11@9@11@9@5xe" filled="f" stroked="f"> <v:stroke joinstyle="miter"/> <v:formulas> <v:f eqn="if lineDrawn pixelLineWidth 0"/> <v:f eqn="sum @0 1 0"/> <v:f eqn="sum 0 0 @1"/> <v:f eqn="prod @2 1 2"/> <v:f eqn="prod @3 21600 pixelWidth"/> <v:f eqn="prod @3 21600 pixelHeight"/> <v:f eqn="sum @0 0 1"/> <v:f eqn="prod @6 1 2"/> <v:f eqn="prod @7 21600 pixelWidth"/> <v:f eqn="sum @8 21600 0"/> <v:f eqn="prod @7 21600 pixelHeight"/> <v:f eqn="sum @10 21600 0"/> </v:formulas> <v:path o:extrusionok="f" gradientshapeok="t" o:connecttype="rect"/> <o:lock v:ext="edit" aspectratio="t"/> </v:shapetype><v:shape id="_x0000_i1025" type="#_x0000_t75" style='width:313pt; height:241pt'> <v:imagedata src="RIO_files/image001.png" o:title="Platform" croptop="1916f" cropbottom="1916f" cropleft="6962f" cropright="8402f"/> </v:shape><![endif]--><!--[if !vml]--><img src="RIO_files/image002.png" v:shapes="_x0000_i1025" border="0" height="243" width="315"><!--[endif]--><o:p></o:p></span></p> <p style="border: medium none ; margin: 0.1pt 0cm; padding: 0cm; text-align: justify;"><span class="GramE"><span style="font-size: 14pt; font-family: Arial;">Multi-step approach using the resources of the Marseille <i style="">C.&nbsp;elegans</i> functional genomics platform.</span></span><span style="font-size: 14pt; font-family: Arial;"><span style="">&nbsp; </span>The black boxed elements are part of the platform located at the CIML.<span style="">&nbsp; </span><a href="http://elegans.imbb.forth.gr/nemagenetag/"><span class="SpellE">Nemagenetag</span></a> is a consortium of 6 European <i style="">C.&nbsp;elegans</i> laboratories, including those of JL. <span class="SpellE">Bessereau</span> (Paris) and L. <span class="SpellE">Segalat</span> (Lyon).<o:p></o:p></span></p> </div> </div> <p style="margin: 0.1pt 0cm;"><span style="font-size: 14pt; font-family: Arial;"><o:p>&nbsp;</o:p></span></p> <p style="margin: 0.1pt 0cm;"><span style="font-size: 14pt; font-family: Arial;">The CNRS recently created a <a href="http://www.univ-lyon1.fr/UR272/0/fiche___laboratoire/">service unit in Lyon</a> dedicated to <i style="">C. elegans</i>. The Marseille and Lyon structures have agreed in principal to become a federated platform. In the near future, therefore, applications to use the resources at Marseille will be channeled through a joint Lyon-Marseille website. For the time being, however, groups wishing to use the platform should submit a project (1 page maximum) to <a href="mailto:ewbank@ciml.univ-mrs.fr">Jonathan Ewbank</a>, explaining concisely the need to have access to the platform and the scientific rationale for the proposed use. Projects may be submitted at any time. They will be evaluated by the platform's <a href="SortComm.html">Steering <span class="SpellE">Commitee</span></a>.<o:p></o:p></span></p> <p style="margin: 0.1pt 0cm;"><span style="font-size: 14pt; font-family: Arial;"><o:p>&nbsp;</o:p></span></p> <p style="margin: 0.1pt 0cm;"><span style="font-size: 14pt; font-family: Arial;">Priority will be given to French laboratories, who will be required to make a nominal contribution to running costs. Depending on demand, researchers in other countries may be able to use the platform on a full fee-paying basis.<o:p></o:p></span></p> <p style="margin: 0.1pt 0cm;"><span style="font-size: 14pt; font-family: Arial;"><o:p>&nbsp;</o:p></span></p> <p style="margin: 0.1pt 0cm;"><span style="font-size: 14pt; font-family: Arial;"><o:p>&nbsp;</o:p></span></p> <p class="MsoNormal" style="text-align: center;" align="center"><span style="font-size: 14pt; font-family: Arial;">Return to the <a href="JE-PRES-A01.htm">Ewbank lab webpages</a><o:p></o:p></span></p> <p style="margin: 0.1pt 0cm;"><span style="font-size: 14pt; font-family: Arial;">&nbsp; <o:p></o:p></span></p> </div> </body></html>