C.
elegans as a Model for the Study of Host-Pathogen
Interactions
Jonathan Ewbank,
Carole Couillault, Sophie Cypowyj, Ilka Engelmann, Léo Kurz, Kwang-Zin Lee,
Frederic Montanana Sanchis, Nathalie Pujol, Barbara Squiban, Katja Ziegler,
Olivier Zugasti. Former members.
C. elegans
is a widely used invertebrate model organism. See it in these 3D models.
We are using worms to investigate the molecular and cellular basis of innate
immunity.
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Part
of the International Ph.D. Program in Molecular
Medicine |
French C. elegans labs come together each year for a meeting
SOME
PUBLICATIONS or see the list at
Ziegler K, Kurz CL, Cypowyj S,
Couillault C, Pophillat M, Pujol N and Ewbank JJ.
Antifungal innate immunity in C.
elegans: PKCdelta
links G protein signaling and a conserved p38 MAPK cascade.
Cell Host Microbe. 2009 5:341-352. [abstract] [pdf] [supplementary data]
See the accompanying
commentary.
Zugasti O and Ewbank JJ.
Neuroimmune regulation of
antimicrobial peptide expression by a noncanonical TGF-beta signaling pathway
in Caenorhabditis elegans epidermis.
Nature Immunology. 2009 10:249-256. [abstract] [pdf] [supplementary
data]
Pujol N, Cypowyj S, Ziegler K,
Millet A, Astrain A, Goncharov A, Jin Y, Chisholm AD and Ewbank JJ.
Distinct innate immune responses to
infection and wounding in the C. elegans epidermis.
Curr Biol. 2008 18:481-489. [abstract]
[pdf]
Faculty of 1000 “Must Read” paper.
Pujol N, Zugasti O, Wong D,
Couillault C, Kurz CL, Schulenburg H and Ewbank JJ.
Anti-fungal innate immunity in C.
elegans is enhanced
by evolutionary diversification of antimicrobial peptides.
PLoS Pathog. 2008 4:e1000105. [Open
Access Article]
Wong D., Bazopoulou D., Pujol N.,
Tavernarakis N. and Ewbank J. J. (2007)
Genome-wide
investigation reveals pathogen-specific and shared signatures in the response
of Caenorhabditis elegans to infection.
Genome Biol. 2007 8:R194 [Open Access Article ] 
Faculty of 1000
“Exceptional” paper
Pradel E., Zhang Y.,
Pujol N.,
Detection
and avoidance of a natural product from the pathogenic bacterium Serratia
marcescens by Caenorhabditis elegans.
PNAS. 104, 2295-2300. [Open Access
Article]
Couillault C., Pujol N.,
Reboul J., Sabatier L., Guichou J.F., Kohara Y. and Ewbank J.J. (2004)
TLR-independent
control of innate immunity in Caenorhabditis elegans by the TIR domain
adaptor protein TIR-1, an ortholog of human SARM.
Nature Immunology 5, 488-494. [abstract] [pdf] [supplementary data]
See these
commentaries in Nature
Immunology and Nature
Reviews Immunology
Faculty of 1000 “Recommended”
paper.
C.L.Kurz
et al. (2003)
Virulence factors of the human opportunistic pathogen Serratia marcescens identified
by in vivo screening.
EMBO J. 22, 1451-1460. [abstract][supplementarydata]
[S. marcescens genome
project]
Faculty of 1000
“Recommended” paper.
Mallo
G.V., Kurz C.L., Couillault C., Pujol N., Granjeaud S., Kohara Y. and Ewbank
J.J. (2002)
Inducible Antibacterial Defense System in C. elegans
Current Biology 12, 1209-1214.[abstract] [pdf]
[supplementary
data]
See
these commentaries in Nature
Review Genetics and Nature
Immunology
Faculty of 1000 “Must Read” paper.
REVIEWS
C.L.
Kurz and Ewbank J.J. (2007)
Infection
in a dish: high-throughput analyses of bacterial pathogenesis.
Curr. Opinion Microbiol 10, 10-16. [pdf]
Ewbank
J.J. (2006)
Signaling
in the immune response.
Wormbook.
E.
Pradel and Ewbank J.J. (2004)
Genetic models in pathogenesis.
Annual Reviews in Genetics 38, 347-363. [abstract][pdf]
A.C.
Millet and Ewbank J.J. (2004)
Immunity in Caenorhabditis elegans.
Current Opinion in Immunology 16,4-9.
[abstract][article]
H.
Schulenburg, C.L. Kurz and Ewbank J.J. (2004)
Evolution of the innate immune system – the worm perspective.
Immunological Reviews 198, 36-58. [abstract and pdf]
C.L.
Kurz and Ewbank J.J. (2003)
Caenorhabditis elegans: an emerging genetic model for the
study of innate immunity.
Nature Reviews Genetics 4, 380-390. [abstract][pdf]
Ewbank J. J. (2002) Tackling both
sides of the host-pathogen equation with Caenorhabditis elegans
Microbes and Infection 4,247-256.
[abstract and pdf]
Phone : (33) 491 269 472
Fax : (33) 491 269 430
E-mail : ewbank@ciml.univ-mrs.fr